| http://purl.uniprot.org/citations/37118537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37118537 | http://www.w3.org/2000/01/rdf-schema#comment | "A transient, homeostatic transcriptional response can result in transcriptional memory, programming subsequent transcriptional outputs. Transcriptional memory has great but unappreciated potential to alter animal aging as animals encounter a multitude of diverse stimuli throughout their lifespan. Here we show that activating an evolutionarily conserved, longevity-promoting transcription factor, dFOXO, solely in early adulthood of female fruit flies is sufficient to improve their subsequent health and survival in midlife and late life. This youth-restricted dFOXO activation causes persistent changes to chromatin landscape in the fat body and requires chromatin remodelers such as the SWI/SNF and ISWI complexes to program health and longevity. Chromatin remodeling is accompanied by a long-lasting transcriptional program that is distinct from that observed during acute dFOXO activation and includes induction of Xbp1. We show that this later-life induction of Xbp1 is sufficient to curtail later-life mortality. Our study demonstrates that transcriptional memory can profoundly alter how animals age."xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.org/dc/terms/identifier | "doi:10.1038/s43587-022-00312-x"xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/author | "Goncalves A."xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/author | "Alic N."xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/author | "Southall T.D."xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/author | "Svermova T."xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/author | "Dobson A.J."xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/author | "Martinez Corrales G."xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/author | "Voicu D."xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/name | "Nat Aging"xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/pages | "1176-1190"xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/title | "Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1."xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/37118537 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37118537 |
| http://purl.uniprot.org/citations/37118537 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37118537 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFI7-mappedCitation-37118537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37118537 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHB1-mappedCitation-37118537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37118537 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JDA0-mappedCitation-37118537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37118537 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7L1-mappedCitation-37118537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37118537 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGD1-mappedCitation-37118537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37118537 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGN1-mappedCitation-37118537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37118537 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LFX8-mappedCitation-37118537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37118537 |