| http://purl.uniprot.org/citations/37129918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37129918 | http://www.w3.org/2000/01/rdf-schema#comment | "Germline genetic variants influence development of pediatric B cell acute lymphoblastic leukemia (B-ALL). Genome-wide association studies (GWAS) have identified several pediatric B-ALL susceptibility loci. IKZF1 and PAX5, transcription factors involved in B cell development, have been reported as susceptibility genes for B-ALL development. Therefore, we hypothesized that rare variants of genes involved in B cell development would be candidate susceptibility loci for pediatric B-ALL. Thus, we sequenced TCF3, a key transcription factor gene involving in B cell development. Saliva DNA from 527 pediatric patients with pediatric B-ALL in remission who were registered with the Tokyo Children's Cancer Study Group (TCCSG) were examined. As a TCF3 gene-based evaluation, the numbers of rare deleterious germline TCF3 sequence variants in patients with pediatric B-ALL were compared with those in cancer-free individuals using data in public databases. As a TCF3 single-variant evaluation, the frequencies of rare deleterious germline TCF3 sequence variants in patients with pediatric B-ALL were also compared with those in control data. TCF3 gene-based analysis revealed significant associations between rare deleterious variants and pediatric B-ALL development. In addition, TCF3 variant-based analysis showed particularly strong association between variant rs372168347 (three in 521 TCCSG and three in the 15780 gnomAD whole genome analysis cohort, p = 0.0006) and pediatric B-ALL development. TCF3 variants are known to influence B cell maturation and may increase the risk of preleukemic clone emergence."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.org/dc/terms/identifier | "doi:10.1080/08880018.2023.2201302"xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Arakawa Y."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Goto H."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Nakamura K."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Takagi M."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Sato Y."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Takahashi H."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Morio T."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Miyamoto S."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Moriwaki K."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Noguchi Y."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Inukai T."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Sakashita K."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Ota S."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Koike K."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Morita D."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Koh K."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Yuza Y."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Hasegawa D."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Takita J."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Manabe A."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Yanagimachi M."xsd:string |
| http://purl.uniprot.org/citations/37129918 | http://purl.uniprot.org/core/author | "Toyama D."xsd:string |