| http://purl.uniprot.org/citations/37130519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37130519 | http://www.w3.org/2000/01/rdf-schema#comment | "The natural product family of the fusicoccanes (FCs) has been shown to display anti-cancer activity, especially when combined with established therapeutic agents. FCs stabilize 14-3-3 protein-protein interactions (PPIs). Here, we tested combinations of a small library of FCs with interferon α (IFNα) on different cancer cell lines and report a proteomics approach to identify the specific 14-3-3 PPIs that are induced by IFNα and stabilized by FCs in OVCAR-3 cells. Among the identified 14-3-3 target proteins are THEMIS2, receptor interacting protein kinase 2 (RIPK2), EIF2AK2, and several members of the LDB1 complex. Biophysical and structural biology studies confirm these 14-3-3 PPIs as physical targets of FC stabilization, and transcriptome as well as pathway analyses suggest possible explanations for the observed synergistic effect of IFNα/FC treatment on cancer cells. This study elucidates the polypharmacological effects of FCs in cancer cells and identifies potential targets from the vast interactome of 14-3-3s for therapeutic intervention in oncology."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chembiol.2023.04.005"xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Brunsveld L."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Kaiser M."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Higuchi Y."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Kato N."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Ottmann C."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Kaschani F."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Eickhoff J."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Wolf A."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Choidas A."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Arkin M."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Menninger S."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Klebl B."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Andrei S.A."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Centorrino F."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Heilmann G."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Ninck S."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/author | "Andlovic B."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/name | "Cell Chem Biol"xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/pages | "573-590.e6"xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/title | "IFNalpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization."xsd:string |
| http://purl.uniprot.org/citations/37130519 | http://purl.uniprot.org/core/volume | "30"xsd:string |