| http://purl.uniprot.org/citations/37148874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37148874 | http://www.w3.org/2000/01/rdf-schema#comment | "The parathyroid hormone (PTH) 1 receptor (PTH1R) is a G protein-coupled receptor (GPCR) that regulates skeletal development and calcium homeostasis. Here, we describe cryo-EM structures of the PTH1R in complex with fragments of the two hormones, PTH and PTH-related protein, the drug abaloparatide, as well as the engineered tool compounds, long-acting PTH (LA-PTH) and the truncated peptide, M-PTH(1-14). We found that the critical N terminus of each agonist engages the transmembrane bundle in a topologically similar fashion, reflecting similarities in measures of Gαs activation. The full-length peptides induce subtly different extracellular domain (ECD) orientations relative to the transmembrane domain. In the structure bound to M-PTH, the ECD is unresolved, demonstrating that the ECD is highly dynamic when unconstrained by a peptide. High resolutions enabled identification of water molecules near peptide and G protein binding sites. Our results illuminate the action of orthosteric agonists of the PTH1R."xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2023.04.002"xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/author | "Belousoff M.J."xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/author | "Sexton P.M."xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/author | "Wootten D."xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/author | "Cary B.P."xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/author | "Fletcher M.M."xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/author | "Piper S.J."xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/author | "Gerrard E.J."xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/author | "Russell I.C."xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/pages | "668-676.e5"xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/title | "Molecular insights into peptide agonist engagement with the PTH receptor."xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/37148874 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37148874 |
| http://purl.uniprot.org/citations/37148874 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37148874 |
| http://purl.uniprot.org/uniprot/#_P63092-mappedCitation-37148874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37148874 |
| http://purl.uniprot.org/uniprot/#_Q03431-mappedCitation-37148874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37148874 |
| http://purl.uniprot.org/uniprot/#_P01270-mappedCitation-37148874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37148874 |
| http://purl.uniprot.org/uniprot/#_P12272-mappedCitation-37148874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37148874 |
| http://purl.uniprot.org/uniprot/#_P59768-mappedCitation-37148874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37148874 |
| http://purl.uniprot.org/uniprot/#_P62873-mappedCitation-37148874 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37148874 |