| http://purl.uniprot.org/citations/37149693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37149693 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 34 (IL-34) mainly plays physiologic and pathologic roles through the sophisticated multi-ligand signaling system, macrophage colony-stimulating factor (M-CSF, CSF-1)/IL-34-CSF-1R axis, which exhibits functional redundancy, tissue-restriction and diversity. This axis is vital for the survival, differentiation and function of monocytic lineage cells and plays pathologic roles in a broad range of diseases. However, the role of IL-34 in leukemia has not been established. Here MLL-AF9 induced mouse acute myeloid leukemia (AML) model overexpressing IL-34 (MA9-IL-34) was used to explore its role in AML. MA9-IL-34 mice exhibited accelerated disease progression and short survival time with significant subcutaneous infiltration of AML cells. MA9-IL-34 cells showed increased proliferation. In vitro colony forming assays and limiting dilution transplantation experiments demonstrated that MA9-IL-34 cells had elevated leukemia stem cell (LSC) levels. Gene expression microarray analysis revealed a panel of differential expressed genes including Sex-determining region Y (SRY)-box 13 (Sox13). Furthermore, a positive correlation between the expressions of IL-34 and Sox13 was detected human datasets. Knockdown of Sox13 rescued the enhanced proliferation, high LSC level and subcutaneous infiltration in MA9-IL-34 cells. Moreover, more leukemia-associated macrophages (LAMs) were detected in MA9-IL-34 microenvironment. Additionally, those LAMs showed M2-like phenotype since they expressed high level of M2-associated genes and had attenuated phagocytic potential, suggesting that LAMs should also contribute to IL-34 caused adverse phenotypes. Therefore, our findings uncover the intrinsic and microenvironmental mechanisms of IL-34 in AML and broadens the knowledge of M-CSF/IL-34-CSF-1R axis in malignancies."xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-023-05822-z"xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/author | "Cui X."xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/author | "Dai Y."xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/author | "Ren Q."xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/author | "Zheng G."xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/pages | "308"xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/title | "Sox13 and M2-like leukemia-associated macrophages contribute to endogenous IL-34 caused accelerated progression of acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37149693 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37149693 |
| http://purl.uniprot.org/citations/37149693 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37149693 |
| http://purl.uniprot.org/uniprot/#_B4DX26-mappedCitation-37149693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37149693 |
| http://purl.uniprot.org/uniprot/#_B4E3N9-mappedCitation-37149693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37149693 |
| http://purl.uniprot.org/uniprot/#_Q9UN79-mappedCitation-37149693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37149693 |
| http://purl.uniprot.org/uniprot/B4E3N9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37149693 |
| http://purl.uniprot.org/uniprot/Q9UN79 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37149693 |
| http://purl.uniprot.org/uniprot/B4DX26 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37149693 |