| http://purl.uniprot.org/citations/37155368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37155368 | http://www.w3.org/2000/01/rdf-schema#comment | "AbstractSix-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) is a key regulator of glycolytic enzyme. This study identified whether PFKFB2 can regulate myocardial ferroptosis in ischemia/reperfusion (I/R) injury. Mice myocardial (I/R) injury and H9c2 cells oxygen-glucose deprivation/reperfusion (OGD/R) models were established. PFKFB2 expression was enhanced in I/R mice and OGD/R H9c2 cells. Overexpression of PFKFB2 improves heart function in I/R mice. Overexpression of PFKFB2 inhibits I/R and OGD/R-induced ferroptosis in mice and H9c2 cells. Mechanistically, overexpression of PFKFB2 activates the adenosine monophosphate-activated protein kinase (AMPK). AMPK inhibitor compound C reverses effect of PFKFB2 overexpression in reducing ferroptosis under OGD/R treatment. In conclusion, PFKFB2 protects hearts against I/R-induced ferroptosis through activation of the AMPK signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://purl.org/dc/terms/identifier | "doi:10.1097/fjc.0000000000001437"xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://purl.uniprot.org/core/author | "Yu S."xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://purl.uniprot.org/core/author | "Fu C."xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://purl.uniprot.org/core/author | "Su G."xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37155368 | http://purl.uniprot.org/core/name | "J Cardiovasc Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://purl.uniprot.org/core/pages | "128-137"xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://purl.uniprot.org/core/title | "PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate-Activated Protein Kinase Activation."xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://purl.uniprot.org/core/volume | "82"xsd:string |
| http://purl.uniprot.org/citations/37155368 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37155368 |
| http://purl.uniprot.org/citations/37155368 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37155368 |
| http://purl.uniprot.org/uniprot/#_B0FLL3-mappedCitation-37155368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37155368 |
| http://purl.uniprot.org/uniprot/#_B2Z891-mappedCitation-37155368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37155368 |
| http://purl.uniprot.org/uniprot/#_B2Z892-mappedCitation-37155368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37155368 |
| http://purl.uniprot.org/uniprot/#_B2Z893-mappedCitation-37155368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37155368 |
| http://purl.uniprot.org/uniprot/#_B2Z894-mappedCitation-37155368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37155368 |
| http://purl.uniprot.org/uniprot/#_B2Z895-mappedCitation-37155368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37155368 |
| http://purl.uniprot.org/uniprot/#_Q8CDS6-mappedCitation-37155368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37155368 |
| http://purl.uniprot.org/uniprot/#_P70265-mappedCitation-37155368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37155368 |
| http://purl.uniprot.org/uniprot/#_Q6GTL7-mappedCitation-37155368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37155368 |