| http://purl.uniprot.org/citations/37161987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37161987 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerging evidence has proved that inflammatory responses aggravate the pathological progression of Parkinson's disease. This study aimed to identify the role of Interleukin-1 receptor-associated kinase-M (IRAK-M) as an important negative regulator of innate immunity, in the pathological progression of Parkinson's disease. In the present study, a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection was administered to prepare the acute and sub-acute Parkinson's disease mouse models. Western blot analysis was utilized to examine the protein expressions of tyrosine hydroxylase and IRAK-M. The mRNA expression levels of IRAK-M, interleukin (IL)-6, IL-β, and cyclooxygenase-2 were evaluated via using reverse transcription quantitative PCR (RT-qPCR). The expression of tyrosine hydroxylase-positive neurons in corpus striatum and substantia nigra pars compacta (SNc) tissues was detected using immunohistochemistry. The results showed that the protein and mRNA levels of IRAK-M were considerably upregulated in corpus striatum and SNc tissues in the sub-acute Parkinson's disease model. Furthermore, IRAK-M knockout significantly enhanced the MPTP-induced loss of tyrosine hydroxylase-positive fibers in corpus striatum and tyrosine hydroxylase-positive neurons in SNc, and intensified the effect of MPTP on the activation of microglial cells and the expression of inflammatory cytokines. In addition, sub-acute Parkinson's disease mice with IRAK-M deletion exhibited worse motor abilities than those of wild-type littermates. Overall, the present study suggested that IRAK-M reduces dopaminergic neuron damage in sub-acute Parkinson's disease by suppressing inflammation, which may provide a new therapeutic target for Parkinson's disease treatment."xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.org/dc/terms/identifier | "doi:10.1097/wnr.0000000000001913"xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/author | "Deng Y."xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/author | "Huang P."xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/author | "Liao Y."xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/author | "Yao Y."xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/author | "Weng G."xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/name | "Neuroreport"xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/pages | "463-470"xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/title | "IRAK-M deficiency exacerbates dopaminergic neuronal damage in a mouse model of sub-acute Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/37161987 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37161987 |
| http://purl.uniprot.org/citations/37161987 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37161987 |
| http://purl.uniprot.org/uniprot/#_Q0VB14-mappedCitation-37161987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37161987 |
| http://purl.uniprot.org/uniprot/#_Q8K4B2-mappedCitation-37161987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37161987 |
| http://purl.uniprot.org/uniprot/Q0VB14 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37161987 |
| http://purl.uniprot.org/uniprot/Q8K4B2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37161987 |