| http://purl.uniprot.org/citations/37167337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37167337 | http://www.w3.org/2000/01/rdf-schema#comment | "RNA Polymerase I (Pol I) has recently been recognized as a cancer therapeutic target. The activity of this enzyme is essential for ribosome biogenesis and is universally activated in cancers. The enzymatic activity of this multi-subunit complex resides in its catalytic core composed of RPA194, RPA135, and RPA12, a subunit with functions in RNA cleavage, transcription initiation and elongation. Here we explore whether RPA12 influences the regulation of RPA194 in human cancer cells. We use a specific small-molecule Pol I inhibitor BMH-21 that inhibits transcription initiation, elongation and ultimately activates the degradation of Pol I catalytic subunit RPA194. We show that silencing RPA12 causes alterations in the expression and localization of Pol I subunits RPA194 and RPA135. Furthermore, we find that despite these alterations not only does the Pol I core complex between RPA194 and RPA135 remain intact upon RPA12 knockdown, but the transcription of Pol I and its engagement with chromatin remain unaffected. The BMH-21-mediated degradation of RPA194 was independent of RPA12 suggesting that RPA12 affects the basal expression, but not the drug-inducible turnover of RPA194. These studies add to knowledge defining regulatory factors for the expression of this Pol I catalytic subunit."xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0285660"xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/author | "Fan W."xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/author | "Wei T."xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/author | "Schneider D.A."xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/author | "Laiho M."xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/author | "Pitts S."xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/author | "Ford B.L."xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/author | "Scull C.E."xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/author | "Najmi S.M."xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/pages | "e0285660"xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/title | "Expression of RNA polymerase I catalytic core is influenced by RPA12."xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/37167337 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37167337 |
| http://purl.uniprot.org/citations/37167337 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37167337 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X8Y8-mappedCitation-37167337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37167337 |
| http://purl.uniprot.org/uniprot/#_B7Z1W6-mappedCitation-37167337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37167337 |
| http://purl.uniprot.org/uniprot/#_B7Z284-mappedCitation-37167337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37167337 |
| http://purl.uniprot.org/uniprot/#_B7ZKR9-mappedCitation-37167337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37167337 |
| http://purl.uniprot.org/uniprot/#_B7Z8X7-mappedCitation-37167337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37167337 |
| http://purl.uniprot.org/uniprot/#_O95602-mappedCitation-37167337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37167337 |