| http://purl.uniprot.org/citations/37174682 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37174682 | http://www.w3.org/2000/01/rdf-schema#comment | "As autophagy can promote or inhibit inflammation, we examined autophagy-inflammation interplay in COVID-19. Autophagy markers in the blood of 19 control subjects and 26 COVID-19 patients at hospital admission and one week later were measured by ELISA, while cytokine levels were examined by flow cytometric bead immunoassay. The antiviral IFN-α and proinflammatory TNF, IL-6, IL-8, IL-17, IL-33, and IFN-γ were elevated in COVID-19 patients at both time points, while IL-10 and IL-1β were increased at admission and one week later, respectively. Autophagy markers LC3 and ATG5 were unaltered in COVID-19. In contrast, the concentration of autophagic cargo receptor p62 was significantly lower and positively correlated with TNF, IL-10, IL-17, and IL-33 at hospital admission, returning to normal levels after one week. The expression of SARS-CoV-2 proteins NSP5 or ORF3a in THP-1 monocytes caused an autophagy-independent decrease or autophagy-inhibition-dependent increase, respectively, of intracellular/secreted p62, as confirmed by immunoblot/ELISA. This was associated with an NSP5-mediated decrease in TNF/IL-10 mRNA and an ORF3a-mediated increase in TNF/IL-1β/IL-6/IL-10/IL-33 mRNA levels. A genetic knockdown of p62 mimicked the immunosuppressive effect of NSP5, and a p62 increase in autophagy-deficient cells mirrored the immunostimulatory action of ORF3a. In conclusion, the proinflammatory autophagy receptor p62 is reduced inacute COVID-19, and the balance between autophagy-independent decrease and autophagy blockade-dependent increase of p62 levels could affect SARS-CoV-induced inflammation."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.org/dc/terms/identifier | "doi:10.3390/cells12091282"xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Nikolic M."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Mandic M."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Trajkovic V."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Stevanovic D."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Perovic V."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Paunovic V."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Harhaji-Trajkovic L."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Ristic B."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Vucicevic L."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Bonaci-Nikolic B."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Bosnjak M."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Lalosevic J."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/author | "Misirkic Marjanovic M."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/name | "Cells"xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/pages | "1282"xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/title | "Autophagy Receptor p62 Regulates SARS-CoV-2-Induced Inflammation in COVID-19."xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/37174682 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37174682 |
| http://purl.uniprot.org/citations/37174682 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37174682 |
| http://purl.uniprot.org/uniprot/#_P37198-mappedCitation-37174682 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37174682 |
| http://purl.uniprot.org/uniprot/#_Q8WYU3-mappedCitation-37174682 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37174682 |