| http://purl.uniprot.org/citations/37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37181748 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the Eya family, which are a class of transcription factors with phosphatase activity, are widely expressed in cranial sensory organs during development. However, it is unclear whether these genes are expressed in the taste system during development and whether they play any role in specifying taste cell fate. In this study, we report that Eya1 is not expressed during embryonic tongue development but that Eya1-expressing progenitors in somites or pharyngeal endoderm give rise to tongue musculature or taste organs, respectively. In the Eya1-deficient tongues, these progenitors do not proliferate properly, resulting in a smaller tongue at birth, impaired growth of taste papillae, and disrupted expression of Six1 in the papillary epithelium. On the other hand, Eya2 is specifically expressed in endoderm-derived circumvallate and foliate papillae located on the posterior tongue during development. In adult tongues, Eya1 is predominantly expressed in IP3R3-positive taste cells in the taste buds of the circumvallate and foliate papillae, while Eya2 is persistently expressed in these papillae at higher levels in some epithelial progenitors and at lower levels in some taste cells. We found that conditional knockout of Eya1 in the third week or Eya2 knockout reduced Pou2f3+, Six1+ and IP3R3+ taste cells. Our data define for the first time the expression patterns of Eya1 and Eya2 during the development and maintenance of the mouse taste system and suggest that Eya1 and Eya2 may act together to promote lineage commitment of taste cell subtypes."xsd:string |
| http://purl.uniprot.org/citations/37181748 | http://purl.org/dc/terms/identifier | "doi:10.3389/fcell.2023.1126968"xsd:string |
| http://purl.uniprot.org/citations/37181748 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/37181748 | http://purl.uniprot.org/core/author | "Xu P.X."xsd:string |
| http://purl.uniprot.org/citations/37181748 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37181748 | http://purl.uniprot.org/core/name | "Front Cell Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/37181748 | http://purl.uniprot.org/core/pages | "1126968"xsd:string |
| http://purl.uniprot.org/citations/37181748 | http://purl.uniprot.org/core/title | "The role of Eya1 and Eya2 in the taste system of mice from embryonic stage to adulthood."xsd:string |
| http://purl.uniprot.org/citations/37181748 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/37181748 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37181748 |
| http://purl.uniprot.org/citations/37181748 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37181748 |
| http://purl.uniprot.org/uniprot/#_A0A087WQF4-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWU2-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWW5-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY47-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY91-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_A0A087WNY3-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_A0A087WSJ4-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_A0A087WRG6-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_F6YST4-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_O88682-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_E9Q589-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |
| http://purl.uniprot.org/uniprot/#_E9QB01-mappedCitation-37181748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37181748 |