| http://purl.uniprot.org/citations/37185848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37185848 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatitis B virus (HBV) specific T cell immune response plays a vital role in viral clearance. Dendritic cell derived exosomes (Dexs) can activate T cell immunity effectively. Tapasin (TPN) is involved in antigen processing and specific immune recognition. In the present study, we elucidated that Dexs loading TPN (TPN-Dexs) could enhance CD8+ T cell immune response and inhibit virus replication in HBV transgenic mice. T cell immune response and the ability of inhibiting HBV replication were measured in HBV transgenic mice immunized with TPN-Dexs. Meanwhile, CD8+ T cell autophagy and specific T cell immune responses were measured in vitro and vivo, and the mechanisms probably involved in were explored. Purified TPN-Dexs could be taken up into the cytoplasm of DCs and upregulate CD8+ T cell autophagy to enhance specific T cell immune response. In addition, TPN-Dexs could increase the expression of AKT and decrease the expression of mTOR in CD8+ T cells. Further research confirmed that TPN-Dexs could inhibit virus replication and decrease the expression of HBsAg in the liver of HBV transgenic mice. Nevertheless, those also could elicit mice hepatocytes damage. In conclusion, TPN-Dexs could enhance specific CD8+ T cell immune responses via the AKT/mTOR pathway to regulate the autophagy and exert the antiviral effect in HBV transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.org/dc/terms/identifier | "doi:10.1002/jmv.28746"xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/author | "Ma S."xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/author | "Tang Z."xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/author | "Yao T."xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/author | "Lv M."xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/author | "Zang G."xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/name | "J Med Virol"xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/pages | "e28746"xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/title | "Exosomes loading Tapasin enhance T cell immune response by autophagy to inhibit HBV replication."xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/37185848 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37185848 |
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