| http://purl.uniprot.org/citations/37191320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37191320 | http://www.w3.org/2000/01/rdf-schema#comment | "The endoplasmic reticulum (ER) undergoes selective autophagy called reticulophagy or ER-phagy. Multiple reticulon- and receptor expression enhancing protein (REEP)-like ER-shaping proteins, including budding yeast Atg40, serve as reticulophagy receptors that stabilize the phagophore on the ER by interacting with phagophore-conjugated Atg8. Additionally, they facilitate phagophore engulfment of the ER by remodeling ER morphology. We reveal that Hva22, a REEP family protein in fission yeast, promotes reticulophagy without Atg8-binding capacity. The role of Hva22 in reticulophagy can be replaced by expressing Atg40 independently of its Atg8-binding ability. Conversely, adding an Atg8-binding sequence to Hva22 enables it to substitute for Atg40 in budding yeast. Thus, the phagophore-stabilizing and ER-shaping activities, both of which Atg40 solely contains, are divided between two separate factors, receptors and Hva22, respectively, in fission yeast.Abbreviations: AIM: Atg8-family interacting motif; Atg: autophagy related; DTT: dithiothreitol; ER: endoplasmic reticulum GFP: green fluorescent protein; NAA: 1-naphthaleneacetic acid; REEP: receptor expression enhancing protein; RFP: red fluorescent protein; UPR: unfolded protein response."xsd:string |
| http://purl.uniprot.org/citations/37191320 | http://purl.org/dc/terms/identifier | "doi:10.1080/15548627.2023.2214029"xsd:string |
| http://purl.uniprot.org/citations/37191320 | http://purl.uniprot.org/core/author | "Inoue K."xsd:string |
| http://purl.uniprot.org/citations/37191320 | http://purl.uniprot.org/core/author | "Fukuda T."xsd:string |
| http://purl.uniprot.org/citations/37191320 | http://purl.uniprot.org/core/author | "Furukawa K."xsd:string |
| http://purl.uniprot.org/citations/37191320 | http://purl.uniprot.org/core/author | "Kanki T."xsd:string |
| http://purl.uniprot.org/citations/37191320 | http://purl.uniprot.org/core/author | "Saigusa T."xsd:string |
| http://purl.uniprot.org/citations/37191320 | http://purl.uniprot.org/core/author | "Yamashita S.I."xsd:string |
| http://purl.uniprot.org/citations/37191320 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37191320 | http://purl.uniprot.org/core/name | "Autophagy"xsd:string |
| http://purl.uniprot.org/citations/37191320 | http://purl.uniprot.org/core/pages | "2657-2667"xsd:string |
| http://purl.uniprot.org/citations/37191320 | http://purl.uniprot.org/core/title | "Hva22, a REEP family protein in fission yeast, promotes reticulophagy in collaboration with a receptor protein."xsd:string |
| http://purl.uniprot.org/citations/37191320 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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