| http://purl.uniprot.org/citations/37196061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37196061 | http://www.w3.org/2000/01/rdf-schema#comment | "Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes epidemics of acute and chronic musculoskeletal disease. Here, we analyzed the human B cell response to a CHIKV-like particle-adjuvanted vaccine (PXVX0317) from samples obtained from a phase 2 clinical trial in humans (NCT03483961). Immunization with PXVX0317 induced high levels of neutralizing antibody in serum against CHIKV and circulating antigen-specific B cells up to 6 months after immunization. Monoclonal antibodies (mAbs) generated from peripheral blood B cells of three PXVX0317-vaccinated individuals on day 57 after immunization potently neutralized CHIKV infection, and a subset of these inhibited multiple related arthritogenic alphaviruses. Epitope mapping and cryo-electron microscopy defined two broadly neutralizing mAbs that uniquely bind to the apex of the B domain of the E2 glycoprotein. These results demonstrate the inhibitory breadth and activity of the human B cell response induced by the PXVX0317 vaccine against CHIKV and potentially other related alphaviruses."xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.org/dc/terms/identifier | "doi:10.1126/scitranslmed.ade8273"xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/author | "Fremont D.H."xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/author | "Crowe J.E. Jr."xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/author | "Diamond M.S."xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/author | "Raju S."xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/author | "Earnest J.T."xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/author | "Adams L.J."xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/author | "Vang L."xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/author | "Warfield K."xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/name | "Sci Transl Med"xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/pages | "eade8273"xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/title | "A chikungunya virus-like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans."xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/37196061 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37196061 |
| http://purl.uniprot.org/citations/37196061 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37196061 |
| http://purl.uniprot.org/uniprot/#_Q5XXP3-mappedCitation-37196061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37196061 |
| http://purl.uniprot.org/uniprot/Q5XXP3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37196061 |