| http://purl.uniprot.org/citations/37201584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37201584 | http://www.w3.org/2000/01/rdf-schema#comment | "Pkc53E is the second conventional protein kinase C (PKC) gene expressed in Drosophila photoreceptors; it encodes at least six transcripts generating four distinct protein isoforms including Pkc53E-B whose mRNA is preferentially expressed in photoreceptors. By characterizing transgenic lines expressing Pkc53E-B-GFP, we show Pkc53E-B is localized in the cytosol and rhabdomeres of photoreceptors, and the rhabdomeric localization appears dependent on the diurnal rhythm. A loss of function of pkc53E-B leads to light-dependent retinal degeneration. Interestingly, the knockdown of pkc53E also impacted the actin cytoskeleton of rhabdomeres in a light-independent manner. Here the Actin-GFP reporter is mislocalized and accumulated at the base of the rhabdomere, suggesting that Pkc53E regulates depolymerization of the actin microfilament. We explored the light-dependent regulation of Pkc53E and demonstrated that activation of Pkc53 E can be independent of the phospholipase C PLCβ4/NorpA as degeneration of norpAP24 photoreceptors was enhanced by a reduced Pkc53E activity. We further show that the activation of Pkc53E may involve the activation of Plc21C by Gqα. Taken together, Pkc53E-B appears to exert both constitutive and light-regulated activity to promote the maintenance of photoreceptors possibly by regulating the actin cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/37201584 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jbc.2023.104822"xsd:string |
| http://purl.uniprot.org/citations/37201584 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/37201584 | http://purl.uniprot.org/core/author | "Shieh B.H."xsd:string |
| http://purl.uniprot.org/citations/37201584 | http://purl.uniprot.org/core/author | "Ferng D."xsd:string |
| http://purl.uniprot.org/citations/37201584 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37201584 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/37201584 | http://purl.uniprot.org/core/pages | "104822"xsd:string |
| http://purl.uniprot.org/citations/37201584 | http://purl.uniprot.org/core/title | "A conventional PKC critical for both the light-dependent and the light-independent regulation of the actin cytoskeleton in Drosophila photoreceptors."xsd:string |
| http://purl.uniprot.org/citations/37201584 | http://purl.uniprot.org/core/volume | "299"xsd:string |
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