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http://purl.uniprot.org/citations/37207452http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/37207452http://www.w3.org/2000/01/rdf-schema#comment"

Context

Autoimmune diabetes can develop at any age, but unlike early-onset diabetes, adult onset is less well documented. We aimed to compare, over a wide age range, the most reliable predictive biomarkers for this pathology: pancreatic-autoantibodies and HLA-DRB1 genotype.

Methods

A retrospective study of 802 patients with diabetes (aged 11 months to 66 years) was conducted. Pancreatic autoantibodies at diagnosis: insulin autoantibodies (IAA), glutamate decarboxylase autoantibodies (GADA), islet tyrosine phosphatase 2 autoantibodies (IA2A), and zinc transporter-8 autoantibodies (ZnT8A) and HLA-DRB1 genotype were analyzed.

Results

Compared with early-onset patients, adults had a lower frequency of multiple autoantibodies, with GADA being the most common. At early onset, IAA was the most frequent in those younger than 6 years and correlated inversely with age; GADA and ZnT8A correlated directly and IA2A remained stable.The absence of HLA-DRB1 risk genotype was associated with higher age at diabetes onset (27.5 years; interquartile range [IQR], 14.3-35.7), whereas the high-risk HLA-DR3/DR4 was significantly more common at lower age (11.9 years; IQR, 7.1-21.6). ZnT8A was associated with DR4/non-DR3 (odds ratio [OR], 1.91; 95% CI, 1.15-3.17), GADA with DR3/non-DR4 (OR, 2.97; 95% CI, 1.55-5.71), and IA2A with DR4/non-DR3 and DR3/DR4 (OR, 3.89; 95% CI, 2.28-6.64, and OR, 3.08; 95% CI, 1.83-5.18, respectively). No association of IAA with HLA-DRB1 was found.

Conclusion

Autoimmunity and HLA-DRB1 genotype are age-dependent biomarkers. Adult-onset autoimmune diabetes is associated with lower genetic risk and lower immune response to pancreatic islet cells compared with early-onset diabetes."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.org/dc/terms/identifier"doi:10.1210/clinem/dgad277"xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/author"Martinez R."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/author"Gonzalez P."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/author"Calvo B."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/author"Castano L."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/author"Rica I."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/author"Gaztambide S."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/author"Urrutia I."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/author"Aguayo A."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/author"Martin-Nieto A."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/author"Fernandez-Rubio E."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/author"Saso-Jimenez L."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/name"J Clin Endocrinol Metab"xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/pages"e1341-e1346"xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/title"Autoimmune Diabetes From Childhood to Adulthood: The Role of Pancreatic Autoantibodies and HLA-DRB1 Genotype."xsd:string
http://purl.uniprot.org/citations/37207452http://purl.uniprot.org/core/volume"108"xsd:string
http://purl.uniprot.org/citations/37207452http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/37207452
http://purl.uniprot.org/citations/37207452http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/37207452
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-37207452http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/37207452
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-37207452http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/37207452
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http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-37207452http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/37207452
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