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| http://purl.uniprot.org/citations/37212449 | http://www.w3.org/2000/01/rdf-schema#comment | "In the last decade, researchers using Drosophila melanogaster have made extraordinary progress in uncovering the mysteries underlying learning and memory. This progress has been propelled by the amazing toolkit available that affords combined behavioral, molecular, electrophysiological, and systems neuroscience approaches. The arduous reconstruction of electron microscopic images resulted in a first-generation connectome of the adult and larval brain, revealing complex structural interconnections between memory-related neurons. This serves as substrate for future investigations on these connections and for building complete circuits from sensory cue detection to changes in motor behavior. Mushroom body output neurons (MBOn) were discovered, which individually forward information from discrete and non-overlapping compartments of the axons of mushroom body neurons (MBn). These neurons mirror the previously discovered tiling of mushroom body axons by inputs from dopamine neurons and have led to a model that ascribes the valence of the learning event, either appetitive or aversive, to the activity of different populations of dopamine neurons and the balance of MBOn activity in promoting avoidance or approach behavior. Studies of the calyx, which houses the MBn dendrites, have revealed a beautiful microglomeruluar organization and structural changes of synapses that occur with long-term memory (LTM) formation. Larval learning has advanced, positioning it to possibly lead in producing new conceptual insights due to its markedly simpler structure over the adult brain. Advances were made in how cAMP response element-binding protein interacts with protein kinases and other transcription factors to promote the formation of LTM. New insights were made on Orb2, a prion-like protein that forms oligomers to enhance synaptic protein synthesis required for LTM formation. Finally, Drosophila research has pioneered our understanding of the mechanisms that mediate permanent and transient active forgetting, an important function of the brain along with acquisition, consolidation, and retrieval. This was catalyzed partly by the identification of memory suppressor genes-genes whose normal function is to limit memory formation."xsd:string |
| http://purl.uniprot.org/citations/37212449 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/iyad085"xsd:string |
| http://purl.uniprot.org/citations/37212449 | http://purl.uniprot.org/core/author | "Davis R.L."xsd:string |
| http://purl.uniprot.org/citations/37212449 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37212449 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
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| http://purl.uniprot.org/citations/37212449 | http://purl.uniprot.org/core/title | "Learning and memory using Drosophila melanogaster: a focus on advances made in the fifth decade of research."xsd:string |
| http://purl.uniprot.org/citations/37212449 | http://purl.uniprot.org/core/volume | "224"xsd:string |
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