| http://purl.uniprot.org/citations/37224650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37224650 | http://www.w3.org/2000/01/rdf-schema#comment | "Pulmonary fibrosis is a chronic progressive disease which steadily causes a critical public health concern. Nesfatin-1, a novel energy-regulating peptide discovered in 2006, could increase the level of AMPK phosphorylation. Previous studies have unveiled that Nesfatin-1 possessed many pharmacological effects including anti-inflammation, anti-oxidative stress, anti-fibrosis, and the regulation of lipid metabolism. Here, we investigated the impact of Nesfatin-1 on pulmonary fibrosis. Male C57BL/6J mice were intraperitoneally injected with Nesfatin-1 (10 μg·kg-1·day-1) for 21 days since mice were intratracheally administrated with bleomycin (BLM) (2 U/kg). Primary murine lung fibroblasts were stimulated with TGF-β1 (10 ng/ml) for 48 h. The results showed that Nesfatin-1 treatment significantly improved pulmonary function and decreased the production of collagen in BLM-treated mice. Meantime, Nesfatin-1 treatment also inhibited oxidative stress and inflammation in lung tissues from BLM-treated mice. Mechanically, Nesfatin-1 blocked the activation of TGF-β1/Smad2/3 signaling pathway in lung tissues challenged with BLM. In addition, we found that Nesfatin-1 enhanced the phosphorylation of AMPKα during pulmonary fibrosis. However, pharmacological inhibition or genetic deletion of AMPKα could both offset the pulmonary protection mediated by Nesfatin-1 during pulmonary fibrosis. Our experimental results firstly show Nesfatin-1 might serve as a novel treatment or adjuvant against pulmonary fibrosis by blocking TGF-β1/Smad pathway in an AMPKα-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.intimp.2023.110369"xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/author | "Hu H."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/author | "Jiang W."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/author | "Liang H."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/author | "Liu G."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/author | "Tang Z."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/author | "Xie S."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/author | "Nie Z."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/author | "Fan Q."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/author | "Kang G."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/name | "Int Immunopharmacol"xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/pages | "110369"xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/title | "Nesfatin-1, a novel energy-regulating peptide, alleviates pulmonary fibrosis by blocking TGF-beta1/Smad pathway in an AMPKalpha-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/37224650 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37224650 |
| http://purl.uniprot.org/citations/37224650 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37224650 |
| http://purl.uniprot.org/uniprot/#_P04202-mappedCitation-37224650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37224650 |
| http://purl.uniprot.org/uniprot/#_Q13131-mappedCitation-37224650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37224650 |
| http://purl.uniprot.org/uniprot/#_Q3UKN6-mappedCitation-37224650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37224650 |
| http://purl.uniprot.org/uniprot/#_Q3UNK5-mappedCitation-37224650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37224650 |
| http://purl.uniprot.org/uniprot/#_P81117-mappedCitation-37224650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37224650 |