| http://purl.uniprot.org/citations/37237031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37237031 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of tumor-intrinsic innate immunity has been a major strategy for improving immunotherapy. Previously, we reported an autophagy-promoting function of the deubiquitinating enzyme TRABID. Here, we identify a critical role of TRABID in suppressing anti-tumor immunity. Mechanistically, TRABID is upregulated in mitosis and governs mitotic cell division by removing K29-linked polyubiquitin chain from Aurora B and Survivin, thereby stabilizing the entire chromosomal passenger complex. TRABID inhibition causes micronuclei through a combinatory defect in mitosis and autophagy and protects cGAS from autophagic degradation, thereby activating the cGAS/STING innate immunity pathway. Genetic or pharmacological inhibition of TRABID promotes anti-tumor immune surveillance and sensitizes tumors to anti-PD-1 therapy in preclinical cancer models in male mice. Clinically, TRABID expression in most solid cancer types correlates inversely with an interferon signature and infiltration of anti-tumor immune cells. Our study identifies a suppressive role of tumor-intrinsic TRABID in anti-tumor immunity and highlights TRABID as a promising target for sensitizing solid tumors to immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-38784-z"xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Chen H.Y."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Chen Y.H."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Lee S.R."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Huang W.S."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Chen H.H."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Kao C.H."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Wang W.J."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Wu K.P."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Chen R.H."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Chan S.J."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Yan R.L."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/author | "Yeat N.Y."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/pages | "3050"xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/title | "TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation."xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37237031 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37237031 |
| http://purl.uniprot.org/citations/37237031 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37237031 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ6-mappedCitation-37237031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37237031 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SQ24-mappedCitation-37237031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37237031 |
| http://purl.uniprot.org/uniprot/#_Q3TQH3-mappedCitation-37237031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37237031 |