| http://purl.uniprot.org/citations/37252939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37252939 | http://www.w3.org/2000/01/rdf-schema#comment | "Epithelial repair relies on the activation of stress signaling pathways to coordinate tissue repair. Their deregulation is implicated in chronic wound and cancer pathologies. Using TNF-α/Eiger-mediated inflammatory damage to Drosophila imaginal discs, we investigate how spatial patterns of signaling pathways and repair behaviors arise. We find that Eiger expression, which drives JNK/AP-1 signaling, transiently arrests proliferation of cells in the wound center and is associated with activation of a senescence program. This includes production of the mitogenic ligands of the Upd family, which allows JNK/AP-1-signaling cells to act as paracrine organizers of regeneration. Surprisingly, JNK/AP-1 cell-autonomously suppress activation of Upd signaling via Ptp61F and Socs36E, both negative regulators of JAK/STAT signaling. As mitogenic JAK/STAT signaling is suppressed in JNK/AP-1-signaling cells at the center of tissue damage, compensatory proliferation occurs by paracrine activation of JAK/STAT in the wound periphery. Mathematical modelling suggests that cell-autonomous mutual repression between JNK/AP-1 and JAK/STAT is at the core of a regulatory network essential to spatially separate JNK/AP-1 and JAK/STAT signaling into bistable spatial domains associated with distinct cellular tasks. Such spatial stratification is essential for proper tissue repair, as coactivation of JNK/AP-1 and JAK/STAT in the same cells creates conflicting signals for cell cycle progression, leading to excess apoptosis of senescently stalled JNK/AP-1-signaling cells that organize the spatial field. Finally, we demonstrate that bistable separation of JNK/AP-1 and JAK/STAT drives bistable separation of senescent signaling and proliferative behaviors not only upon tissue damage, but also in RasV12, scrib tumors. Revealing this previously uncharacterized regulatory network between JNK/AP-1, JAK/STAT, and associated cell behaviors has important implications for our conceptual understanding of tissue repair, chronic wound pathologies, and tumor microenvironments."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.3001665"xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/author | "Kreutz C."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/author | "Timmer J."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/author | "Grass I."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/author | "Classen A.K."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/author | "Jaiswal J."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/author | "Engesser R."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/author | "Weichselberger V."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/author | "Crucianelli C."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/author | "Nogay L."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/author | "Egert J."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/author | "Peyroton A.A."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/pages | "e3001665"xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/title | "Mutual repression between JNK/AP-1 and JAK/STAT stratifies senescent and proliferative cell behaviors during tissue regeneration."xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/37252939 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37252939 |
| http://purl.uniprot.org/citations/37252939 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37252939 |
| http://purl.uniprot.org/uniprot/Q8MUJ1#attribution-5A258BCCD7DC60EB9CD0C7FB1178DE9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/37252939 |
| http://purl.uniprot.org/uniprot/Q8MUJ1#attribution-E0CCBBE01C2A6230FC84D11509CC7407 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/37252939 |
| http://purl.uniprot.org/uniprot/Q23977#attribution-E0CCBBE01C2A6230FC84D11509CC7407 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/37252939 |
| http://purl.uniprot.org/uniprot/Q9W0G1#attribution-E0CCBBE01C2A6230FC84D11509CC7407 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/37252939 |