| http://purl.uniprot.org/citations/37257772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37257772 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular response to hypoxia is mainly governed by a transcription factor, hypoxia-inducible factor 1 (HIF-1). Although upregulation of HIF-1 target genes has been hypothesized to require interaction of HIF-1 with other coactivators, much remains to be elucidated regarding the underlying mechanisms. Here, we demonstrate that zinc finger and BTB domain-containing protein 2 (ZBTB2) enhances the expression of certain HIF-1 target genes under hypoxia. ChIP-Seq analysis showed that there is a subset of HIF-1 target genes with overlapping HIF-1 and ZBTB2 peaks. Examination of a representative gene, EGFR antisense RNA 1 (EGFR-AS1), showed that HIF-1 binding to the consensus hypoxia-responsive element (HRE) sequence resulted in the recruitment of ZBTB2 to the gene locus and increased p300-mediated histone acetylation, leading to enhanced gene expression under hypoxia. In contrast, expression of HIF-1 target genes lacking ZBTB2 peaks, such as carbonic anhydrase 9 (CA9), was not upregulated by ZBTB2. These findings demonstrate that ZBTB2 is a novel factor that can be recruited to the vicinity of HREs on a subset of HIF-1 target gene loci, and is required for their full expression under hypoxia."xsd:string |
| http://purl.uniprot.org/citations/37257772 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2023.168162"xsd:string |
| http://purl.uniprot.org/citations/37257772 | http://purl.uniprot.org/core/author | "Kobayashi M."xsd:string |
| http://purl.uniprot.org/citations/37257772 | http://purl.uniprot.org/core/author | "Harada H."xsd:string |
| http://purl.uniprot.org/citations/37257772 | http://purl.uniprot.org/core/author | "Chow C.C.T."xsd:string |
| http://purl.uniprot.org/citations/37257772 | http://purl.uniprot.org/core/author | "Kambe G."xsd:string |
| http://purl.uniprot.org/citations/37257772 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37257772 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/37257772 | http://purl.uniprot.org/core/pages | "168162"xsd:string |
| http://purl.uniprot.org/citations/37257772 | http://purl.uniprot.org/core/title | "ZBTB2 is Recruited to a Specific Subset of HIF-1 Target Loci to Facilitate Full Gene Expression Under Hypoxia."xsd:string |
| http://purl.uniprot.org/citations/37257772 | http://purl.uniprot.org/core/volume | "435"xsd:string |
| http://purl.uniprot.org/citations/37257772 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37257772 |
| http://purl.uniprot.org/citations/37257772 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37257772 |
| http://purl.uniprot.org/uniprot/#_Q658W5-mappedCitation-37257772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37257772 |
| http://purl.uniprot.org/uniprot/#_Q8N680-mappedCitation-37257772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37257772 |
| http://purl.uniprot.org/uniprot/Q658W5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37257772 |
| http://purl.uniprot.org/uniprot/Q8N680 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37257772 |