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http://purl.uniprot.org/citations/37267956http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/37267956http://www.w3.org/2000/01/rdf-schema#comment"One of cannabis' most iconic effects is the stimulation of hedonic high-calorie eating-the "munchies"-yet habitual cannabis users are, on average, leaner than non-users. We asked whether this phenotype might result from lasting changes in energy balance established during adolescence, when use of the drug often begins. We found that daily low-dose administration of cannabis' intoxicating constituent, Δ9-tetrahydrocannabinol (THC), to adolescent male mice causes an adult metabolic phenotype characterized by reduced fat mass, increased lean mass and utilization of fat as fuel, partial resistance to diet-induced obesity and dyslipidemia, enhanced thermogenesis, and impaired cold- and β-adrenergic receptor-stimulated lipolysis. Further analyses revealed that this phenotype is associated with molecular anomalies in the adipose organ, including ectopic overexpression of muscle-associated proteins and heightened anabolic processing. Thus, adolescent exposure to THC may promote an enduring "pseudo-lean" state that superficially resembles healthy leanness but might in fact be rooted in adipose organ dysfunction."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.org/dc/terms/identifier"doi:10.1016/j.cmet.2023.05.002"xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Huang L."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Lin L."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Le J."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Tang L."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Yang Q."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Yu C."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Ramirez J."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Lee H.L."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Wood C."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Su S."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Cinti S."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Piomelli D."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Jung K.M."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Jang C."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Palese F."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Colleluori G."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Fotio Y."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Torrens A."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"DiPatrizio N."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/author"Squire E."xsd:string
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/37267956http://purl.uniprot.org/core/name"Cell Metab"xsd:string