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| http://purl.uniprot.org/citations/37289586 | http://www.w3.org/2000/01/rdf-schema#comment | "We applied raw human liver microsome lysate to a holey carbon grid and used cryo-electron microscopy (cryo-EM) to define its composition. From this sample we identified and simultaneously determined high-resolution structural information for ten unique human liver enzymes involved in diverse cellular processes. Notably, we determined the structure of the endoplasmic bifunctional protein H6PD, where the N- and C-terminal domains independently possess glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase enzymatic activity, respectively. We also obtained the structure of heterodimeric human GANAB, an ER glycoprotein quality-control machinery that contains a catalytic α subunit and a noncatalytic β subunit. In addition, we observed a decameric peroxidase, PRDX4, which directly contacts a disulfide isomerase-related protein, ERp46. Structural data suggest that several glycosylations, bound endogenous compounds, and ions associate with these human liver enzymes. These results highlight the importance of cryo-EM in facilitating the elucidation of human organ proteomics at the atomic level."xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2023.112609"xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/author | "Yu E.W."xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/author | "Su C.C."xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/author | "Miyagi M."xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/author | "Lyu M."xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/author | "Taylor D.J."xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/pages | "112609"xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/title | "High-resolution structural-omics of human liver enzymes."xsd:string |
| http://purl.uniprot.org/citations/37289586 | http://purl.uniprot.org/core/volume | "42"xsd:string |
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