| http://purl.uniprot.org/citations/37315736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37315736 | http://www.w3.org/2000/01/rdf-schema#comment | "In the maternal circulation, apoB-containing low-density lipoproteins (LDL) and apoA1-containing high-density lipoproteins (HDL) transport lipids. The production of lipoproteins in the placenta has been suggested, but the directionality of release has not been resolved. We compared apolipoprotein concentrations and size-exclusion chromatography elution profiles of lipoproteins in maternal/fetal circulations, and in umbilical arteries/veins; identified placental lipoprotein-producing cells; and studied temporal induction of lipoprotein-synthesizing machinery during pregnancy. We observed that maternal and fetal lipoproteins are different with respect to concentrations and elution profiles. Surprisingly, concentrations and elution profiles of lipoproteins in umbilical arteries and veins were similar indicating their homeostatic control. Human placental cultures synthesized apoB100-containing LDL-sized and apoA1-containing HDL-sized particles. Immunolocalization techniques revealed that ApoA1 was present mainly in syncytiotrophoblasts. MTP, a critical protein for lipoprotein assembly, was in these trophoblasts. ApoB was in the placental stroma indicating that trophoblasts secrete apoB-containing lipoproteins into the stroma. ApoB and MTP expressions increased in placentas from the 2nd trimester to term, whereas apoA1 expression was unchanged. Thus, our studies provide new information regarding the timing of lipoprotein gene induction during gestation, the cells involved in lipoprotein assembly and the gel filtration profiles of human placental lipoproteins. Next, we observed that mouse placenta produces MTP, apoB100, apoB48 and apoA1. The expression of genes gradually increased and peaked in late gestation. This information may be useful in identifying transcription factors regulating the induction of these genes in gestation and the importance of placental lipoprotein assembly in fetal development."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbalip.2023.159357"xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/author | "Kiefer D."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/author | "Hanna N."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/author | "Hussain M.M."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/author | "Giordano E."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/author | "Nargis T."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/author | "Quadro L."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/author | "Suhail S."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/author | "Ijaz L."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/author | "Gurzenda E.M."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Mol Cell Biol Lipids"xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/pages | "159357"xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/title | "Characterization of lipoproteins in human placenta and fetal circulation as well as gestational changes in lipoprotein assembly and secretion in human and mouse placentas."xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://purl.uniprot.org/core/volume | "1868"xsd:string |
| http://purl.uniprot.org/citations/37315736 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37315736 |
| http://purl.uniprot.org/citations/37315736 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37315736 |
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| http://purl.uniprot.org/uniprot/#_E9Q606-mappedCitation-37315736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37315736 |