| http://purl.uniprot.org/citations/37327776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37327776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37327776 | http://www.w3.org/2000/01/rdf-schema#comment | "The heme-regulated kinase HRI is activated under heme/iron deficient conditions; however, the underlying molecular mechanism is incompletely understood. Here, we show that iron-deficiency-induced HRI activation requires the mitochondrial protein DELE1. Notably, mitochondrial import of DELE1 and its subsequent protein stability are regulated by iron availability. Under steady-state conditions, DELE1 is degraded by the mitochondrial matrix-resident protease LONP1 soon after mitochondrial import. Upon iron chelation, DELE1 import is arrested, thereby stabilizing DELE1 on the mitochondrial surface to activate the HRI-mediated integrated stress response (ISR). Ablation of this DELE1-HRI-ISR pathway in an erythroid cell model enhances cell death under iron-limited conditions, suggesting a cell-protective role for this pathway in iron-demanding cell lineages. Our findings highlight mitochondrial import regulation of DELE1 as the core component of a previously unrecognized mitochondrial iron responsive pathway that elicits stress signaling following perturbation of iron homeostasis."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2023.05.031"xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2023.05.031"xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Sekine S."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Sekine S."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Jae L.T."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Jae L.T."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Sekine Y."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Sekine Y."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Eckl E.M."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Eckl E.M."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Fessler E."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Fessler E."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Houston R."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Houston R."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Narendra D.P."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/author | "Narendra D.P."xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/pages | "2059-2076"xsd:string |
| http://purl.uniprot.org/citations/37327776 | http://purl.uniprot.org/core/pages | "2059-2076"xsd:string |