| http://purl.uniprot.org/citations/37329886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37329886 | http://www.w3.org/2000/01/rdf-schema#comment | "Septins self-assemble into polymers that bind and deform membranes in vitro and regulate diverse cell behaviors in vivo. How their in vitro properties relate to their in vivo functions is under active investigation. Here, we uncover requirements for septins in detachment and motility of border cell clusters in the Drosophila ovary. Septins and myosin colocalize dynamically at the cluster periphery and share phenotypes but, surprisingly, do not impact each other. Instead, Rho independently regulates myosin activity and septin localization. Active Rho recruits septins to membranes, whereas inactive Rho sequesters septins in the cytoplasm. Mathematical analyses identify how manipulating septin expression levels alters cluster surface texture and shape. This study shows that the level of septin expression differentially regulates surface properties at different scales. This work suggests that downstream of Rho, septins tune surface deformability while myosin controls contractility, the combination of which governs cluster shape and movement."xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2023.05.017"xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/author | "Myers A."xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/author | "Montell D.J."xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/author | "Campanale J.P."xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/author | "Streichan S.J."xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/author | "Mondo J.A."xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/author | "Mitchell N.P."xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/author | "Gabbert A.M."xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/author | "Miolane N."xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/pages | "1399-1413.e5"xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/title | "Septins regulate border cell surface geometry, shape, and motility downstream of Rho in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://purl.uniprot.org/core/volume | "58"xsd:string |
| http://purl.uniprot.org/citations/37329886 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37329886 |
| http://purl.uniprot.org/citations/37329886 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37329886 |
| http://purl.uniprot.org/uniprot/#_P54359-mappedCitation-37329886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37329886 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGJ1-mappedCitation-37329886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37329886 |
| http://purl.uniprot.org/uniprot/#_C7LAH9-mappedCitation-37329886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37329886 |
| http://purl.uniprot.org/uniprot/#_F6J1D0-mappedCitation-37329886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37329886 |
| http://purl.uniprot.org/uniprot/#_M9NFF8-mappedCitation-37329886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37329886 |
| http://purl.uniprot.org/uniprot/#_M9NG50-mappedCitation-37329886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37329886 |
| http://purl.uniprot.org/uniprot/#_P42207-mappedCitation-37329886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37329886 |