| http://purl.uniprot.org/citations/37329887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37329887 | http://www.w3.org/2000/01/rdf-schema#comment | "Obesity, in which the functional importance of small nucleolar RNAs (snoRNAs) remains elusive, correlates with risk for many cancer types. Here, we identify that the serum copies of adipocyte-expressed SNORD46 correlate with body mass index (BMI), and serum SNORD46 antagonizes interleukin-15 (IL-15) signaling. Mechanically, SNORD46 binds IL-15 via G11, and G11A (a mutation that significantly enhances binding affinity) knockin drives obesity in mice. Functionally, SNORD46 blocks IL-15-induced, FER kinase-dependent phosphorylation of platelet glycoprotein 4 (CD36) and monoglyceride lipase (MGLL) in adipocytes, leading to inhibited lipolysis and browning. In natural killer (NK) cells, SNORD46 suppresses the IL-15-dependent autophagy, leading to reduced viability of obese NK. SNORD46 power inhibitors exhibit anti-obesity effects, concurring with improved viability of obese NK and anti-tumor immunity of CAR-NK cell therapy. Hence, our findings demonstrate the functional importance of snoRNAs in obesity and the utility of snoRNA power inhibitors for antagonizing obesity-associated immune resistance."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2023.05.009"xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Sun C."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Lin C."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Yuan F."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Zhao Z."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Han L."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Beretta L."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Ye Y."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Wu A."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Rezvani K."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Hung M.C."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Lim B."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Calin G.A."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Tan Z."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Sahin A.A."xsd:string |
| http://purl.uniprot.org/citations/37329887 | http://purl.uniprot.org/core/author | "Nguyen T.K."xsd:string |