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http://purl.uniprot.org/citations/37335136http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/37335136http://www.w3.org/2000/01/rdf-schema#comment"Genome damage is a main driver of malignant transformation, but it also induces aberrant inflammation via the cGAS/STING DNA-sensing pathway. Activation of cGAS/STING can trigger cell death and senescence, thereby potentially eliminating genome-damaged cells and preventing against malignant transformation. Here, we report that defective ribonucleotide excision repair (RER) in the hematopoietic system caused genome instability with concomitant activation of the cGAS/STING axis and compromised hematopoietic stem cell function, ultimately resulting in leukemogenesis. Additional inactivation of cGAS, STING, or type I IFN signaling, however, had no detectable effect on blood cell generation and leukemia development in RER-deficient hematopoietic cells. In wild-type mice, hematopoiesis under steady-state conditions and in response to genome damage was not affected by loss of cGAS. Together, these data challenge a role of the cGAS/STING pathway in protecting the hematopoietic system against DNA damage and leukemic transformation.

Significance

Loss of cGAS/STING signaling does not impact DNA damage-driven leukemogenesis or alter steady-state, perturbed or malignant hematopoiesis, indicating that the cGAS/STING axis is not a crucial antioncogenic mechanism in the hematopoietic system. See related commentary by Zierhut, p. 2807."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.org/dc/terms/identifier"doi:10.1158/0008-5472.can-22-3860"xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Behrendt R."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Muller P."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Rosen-Wolff A."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Dahl A."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Lesche M."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Haase C."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Hiller B."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Gerbaulet A."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Roers A."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Luksch H."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Schulze L."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Morcos M.N.F."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Munz C.M."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Dressel N."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Costas Ramon S."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Loff A."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/author"Natusch L."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/name"Cancer Res"xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/pages"2858-2872"xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/title"Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis."xsd:string
http://purl.uniprot.org/citations/37335136http://purl.uniprot.org/core/volume"83"xsd:string
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