| http://purl.uniprot.org/citations/37336990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37336990 | http://www.w3.org/2000/01/rdf-schema#comment | "The interaction between the gastric epithelium and immune cells plays key roles in H. pylori-associated pathology. Here, we demonstrate a procolonization and proinflammatory role of tubulointerstitial nephritis antigen-like 1 (TINAGL1), a newly discovered matricellular protein, in H. pylori infection. Increased TINAGL1 production by gastric epithelial cells (GECs) in the infected gastric mucosa was synergistically induced by H. pylori and IL-1β via the ERK-SP1 pathway in a cagA-dependent manner. Elevated human gastric TINAGL1 correlated with H. pylori colonization and the severity of gastritis, and mouse TINAGL1 derived from non-bone marrow-derived cells promoted bacterial colonization and inflammation. Importantly, H. pylori colonization and inflammation were attenuated in Tinagl1-/- and Tinagl1ΔGEC mice and were increased in mice injected with mouse TINAGL1. Mechanistically, TINAGL1 suppressed CCL21 expression and promoted CCL2 production in GECs by directly binding to integrin α5β1 to inhibit ERK and activate the NF-κB pathway, respectively, which not only led to decreased gastric influx of moDCs via CCL21-CCR7-dependent migration and, as a direct consequence, reduced the bacterial clearance capacity of the H. pylori-specific Th1 response, thereby promoting H. pylori colonization, but also resulted in increased gastric influx of Ly6Chigh monocytes via CCL2-CCR2-dependent migration. In turn, TINAGL1 induced the production of the proinflammatory protein S100A11 by Ly6Chigh monocytes, promoting H. pylori-associated gastritis. In summary, we identified a model in which TINAGL1 collectively ensures H. pylori persistence and promotes gastritis."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41423-023-01055-4"xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Peng L."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Yan Z."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Zou Q."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Tian W."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Cheng P."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Mao F."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Teng Y."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Xie R."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Zhuang Y."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Shan Z."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/author | "Chen W.'"xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/name | "Cell Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/pages | "924-940"xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/title | "Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection."xsd:string |
| http://purl.uniprot.org/citations/37336990 | http://purl.uniprot.org/core/volume | "20"xsd:string |