| http://purl.uniprot.org/citations/37339974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37339974 | http://www.w3.org/2000/01/rdf-schema#comment | "Unconventional T cells, such as innate natural killer T cells (iNKT) cells, are an important part of vertebrate immune defences. iNKT recognise glycolipids through a T cell receptor (TCR) that is composed of a semi-invariant TCR α chain, paired with a restricted set of TCR β chains. Here, we show that splicing of the cognate Trav11-Traj18-Trac pre-mRNA encoding the characteristic Vα14Jα18 variable region of this semi-invariant TCR depends on the presence of Tnpo3. The Tnpo3 gene encodes a nuclear transporter of the β-karyopherin family whose cargo includes various splice regulators. The block of iNKT cell development in the absence of Tnpo3 can be overcome by transgenic provision of a rearranged Trav11-Traj18-Trac cDNA, indicating that Tnpo3 deficiency does not interfere with the development of iNKT cells per se. Our study thus identifies a role for Tnpo3 in regulating the splicing of the pre-mRNA encoding the cognate TCRα chain of iNKT cells."xsd:string |
| http://purl.uniprot.org/citations/37339974 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-39422-4"xsd:string |
| http://purl.uniprot.org/citations/37339974 | http://purl.uniprot.org/core/author | "Boehm T."xsd:string |
| http://purl.uniprot.org/citations/37339974 | http://purl.uniprot.org/core/author | "Iwanami N."xsd:string |
| http://purl.uniprot.org/citations/37339974 | http://purl.uniprot.org/core/author | "Sikora K."xsd:string |
| http://purl.uniprot.org/citations/37339974 | http://purl.uniprot.org/core/author | "Richter A.S."xsd:string |
| http://purl.uniprot.org/citations/37339974 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37339974 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37339974 | http://purl.uniprot.org/core/pages | "3645"xsd:string |
| http://purl.uniprot.org/citations/37339974 | http://purl.uniprot.org/core/title | "Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR alpha chain of iNKT cells."xsd:string |
| http://purl.uniprot.org/citations/37339974 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37339974 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37339974 |
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