| http://purl.uniprot.org/citations/37342906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37342906 | http://www.w3.org/2000/01/rdf-schema#comment | "Triple-negative breast cancer (TNBC) is the most aggressive subtype with limited effective therapies because of the absence of definitive targets. Here, we demonstrate that the expression of ZNF451, a poorly characterized vertebrate zinc-finger protein, is upregulated in TNBC and associated with a poor prognosis. Elevated ZNF451 expression facilitates TNBC progression by interacting with and enhancing the activity of the transcriptional activator snail family transcriptional repressor 2 (SLUG). Mechanistically, the ZNF451-SLUG complex preferentially recruits the acetyltransferase p300/CBP-associated factor (PCAF) to the CCL5 promoter, selectively facilitating CCL5 transcription by enhancing the acetylation of SLUG and local chromatin, leading to recruitment and activation of tumor-associated macrophages (TAMs). Disturbing the ZNF451-SLUG interaction using a peptide suppresses TNBC progression by reducing CCL5 expression and counteracting the migration and activation of TAMs. Collectively, our work provides mechanistic insights into the oncogene-like functions of ZNF451 and suggests that ZNF451 is a potential target for development of effective therapies against TNBC."xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2023.112654"xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/author | "Min J."xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/author | "Liu S.'"xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/pages | "112654"xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/title | "ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression."xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/37342906 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37342906 |
| http://purl.uniprot.org/citations/37342906 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37342906 |
| http://purl.uniprot.org/uniprot/#_D0EI67-mappedCitation-37342906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37342906 |
| http://purl.uniprot.org/uniprot/#_A0A494C1Q1-mappedCitation-37342906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37342906 |
| http://purl.uniprot.org/uniprot/#_B4DYS2-mappedCitation-37342906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37342906 |
| http://purl.uniprot.org/uniprot/#_B2R5J8-mappedCitation-37342906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37342906 |
| http://purl.uniprot.org/uniprot/#_P13501-mappedCitation-37342906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37342906 |