| http://purl.uniprot.org/citations/37343092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37343092 | http://www.w3.org/2000/01/rdf-schema#comment | "Stem cells in many systems, including Drosophila germline stem cells (GSCs), increase ribosome biogenesis and translation during terminal differentiation. Here, we show that the H/ACA small nuclear ribonucleoprotein (snRNP) complex that promotes pseudouridylation of ribosomal RNA (rRNA) and ribosome biogenesis is required for oocyte specification. Reducing ribosome levels during differentiation decreased the translation of a subset of messenger RNAs that are enriched for CAG trinucleotide repeats and encode polyglutamine-containing proteins, including differentiation factors such as RNA-binding Fox protein 1. Moreover, ribosomes were enriched at CAG repeats within transcripts during oogenesis. Increasing target of rapamycin (TOR) activity to elevate ribosome levels in H/ACA snRNP complex-depleted germlines suppressed the GSC differentiation defects, whereas germlines treated with the TOR inhibitor rapamycin had reduced levels of polyglutamine-containing proteins. Thus, ribosome biogenesis and ribosome levels can control stem cell differentiation via selective translation of CAG repeat-containing transcripts."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.ade5492"xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/author | "Peng Y."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/author | "Deng L."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/author | "Fabris D."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/author | "Martin E.T."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/author | "Rangan P."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/author | "Gavis E.R."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/author | "Kotb N.M."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/author | "Breznak S.M."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/author | "Flamholz Z."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/author | "LaBarge K.A."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/author | "Rapisarda I.T."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/pages | "eade5492"xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/title | "H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins."xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/37343092 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37343092 |
| http://purl.uniprot.org/citations/37343092 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37343092 |
| http://purl.uniprot.org/uniprot/O44081#attribution-C05CF442FD70E0C8D43478D6D1134C6F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/37343092 |
| http://purl.uniprot.org/uniprot/O44081#attribution-C468028AD3F47B4D6A14EE650CA46E18 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/37343092 |
| http://purl.uniprot.org/uniprot/Q9V5P6#attribution-C468028AD3F47B4D6A14EE650CA46E18 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/37343092 |
| http://purl.uniprot.org/uniprot/#_E1JGV6-mappedCitation-37343092 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37343092 |