| http://purl.uniprot.org/citations/37347461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37347461 | http://www.w3.org/2000/01/rdf-schema#comment | "Healthy adipose tissue (AT) contains ST2+ Tregs, ILC2s, and alternatively activated macrophages that are lost in mice or humans on high caloric diet. Understanding how this form of type 2 immunity is regulated could improve treatment of obesity. The STE20 kinase Thousand And One amino acid Kinase-3 (TAOK3) has been linked to obesity in mice and humans, but its precise function is unknown. We found that ST2+ Tregs are upregulated in visceral epididymal white AT (eWAT) of Taok3-/-mice, dependent on IL-33 and the kinase activity of TAOK3. Upon high fat diet feeding, metabolic dysfunction was attenuated in Taok3-/-mice. ST2+ Tregs disappeared from eWAT in obese wild-type mice, but this was not the case in Taok3-/- mice. Mechanistically, AT Taok3-/-Tregs were intrinsically more responsive to IL-33, through higher expression of ST2, and expressed more PPARγ and type 2 cytokines. Thus, TAOK3 inhibits adipose tissue Tregs and regulates immunometabolism under excessive caloric intake."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20210788"xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Janssens S."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Maes B."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Van der Schueren B."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Hammad H."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Lambrecht B.N."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Lornet G."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Descamps B."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Deswarte K."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "De Prijck S."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Vanheerswynghels M."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Vanhove C."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Catrysse L."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Vangoitsenhoven R."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Van Moorleghem J."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Fayazpour F."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "De Wolf C."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/author | "Van De Velde E."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/pages | "e20210788"xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/title | "STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity."xsd:string |
| http://purl.uniprot.org/citations/37347461 | http://purl.uniprot.org/core/volume | "220"xsd:string |