| http://purl.uniprot.org/citations/37349313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37349313 | http://www.w3.org/2000/01/rdf-schema#comment | "Musculoskeletal chronic pain is prevalent in individuals with Alzheimer's disease (AD); however, it remains largely untreated in these patients, raising the possibility that pain mechanisms are perturbed. Here, we utilise the TASTPM transgenic mouse model of AD with the K/BxN serum transfer model of inflammatory arthritis. We show that in male and female WT mice, inflammatory allodynia is associated with a distinct spinal cord microglial response characterised by TLR4-driven transcriptional profile and upregulation of P2Y12. Dorsal horn nociceptive afferent terminals release the TLR4 ligand galectin-3 (Gal-3), and intrathecal injection of a Gal-3 inhibitor attenuates allodynia. In contrast, TASTPM mice show reduced inflammatory allodynia, which is not affected by the Gal-3 inhibitor and correlates with the emergence of a P2Y12- TLR4- microglia subset in the dorsal horn. We suggest that sensory neuron-derived Gal-3 promotes allodynia through the TLR4-regulated release of pro-nociceptive mediators by microglia, a process that is defective in TASTPM due to the absence of TLR4 in a microglia subset."xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-39077-1"xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/author | "Silva R."xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/author | "Dharmalingam G."xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/author | "Collier D.A."xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/author | "Bajpai A."xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/author | "Zeboudj L."xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/author | "Malcangio M."xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/author | "Oggero S."xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/author | "Sideris-Lampretsas G."xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/pages | "3579"xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/title | "Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37349313 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37349313 |
| http://purl.uniprot.org/citations/37349313 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37349313 |
| http://purl.uniprot.org/uniprot/#_D3YVT4-mappedCitation-37349313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37349313 |
| http://purl.uniprot.org/uniprot/#_A2BHU8-mappedCitation-37349313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37349313 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRE5-mappedCitation-37349313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37349313 |
| http://purl.uniprot.org/uniprot/#_D3YZJ2-mappedCitation-37349313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37349313 |
| http://purl.uniprot.org/uniprot/#_L0CL36-mappedCitation-37349313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37349313 |
| http://purl.uniprot.org/uniprot/#_Q61357-mappedCitation-37349313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37349313 |
| http://purl.uniprot.org/uniprot/#_Q3V471-mappedCitation-37349313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37349313 |