| http://purl.uniprot.org/citations/37349316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37349316 | http://www.w3.org/2000/01/rdf-schema#comment | "In mammals, the production of mature oocytes necessitates rigorous regulation of the discontinuous meiotic cell-cycle progression at both the transcriptional and post-transcriptional levels. However, the factors underlying this sophisticated but explicit process remain largely unclear. Here we characterize the function of N-acetyltransferase 10 (Nat10), a writer for N4-acetylcytidine (ac4C) on RNA molecules, in mouse oocyte development. We provide genetic evidence that Nat10 is essential for oocyte meiotic prophase I progression, oocyte growth and maturation by sculpting the maternal transcriptome through timely degradation of poly(A) tail mRNAs. This is achieved through the ac4C deposition on the key CCR4-NOT complex transcripts. Importantly, we devise a method for examining the poly(A) tail length (PAT), termed Hairpin Adaptor-poly(A) tail length (HA-PAT), which outperforms conventional methods in terms of cost, sensitivity, and efficiency. In summary, these findings provide genetic evidence that unveils the indispensable role of maternal Nat10 in oocyte development."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-39256-0"xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Cheng Y."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Bao J."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Cao Y."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Zou J."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Qin W."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Tong X."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Meng L."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Xing X."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/author | "Azhar M."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/pages | "3729"xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/title | "Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice."xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37349316 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37349316 |
| http://purl.uniprot.org/citations/37349316 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37349316 |