| http://purl.uniprot.org/citations/37353485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37353485 | http://www.w3.org/2000/01/rdf-schema#comment | "Pancreatic acinar cells rely on PTF1 and other transcription factors to deploy their transcriptional program. We identify NFIC as a NR5A2 interactor and regulator of acinar differentiation. NFIC binding sites are enriched in NR5A2 ChIP-Sequencing peaks. Nfic knockout mice have a smaller, histologically normal, pancreas with reduced acinar gene expression. NFIC binds and regulates the promoters of acinar genes and those involved in RNA/protein metabolism, and Nfic knockout pancreata show defective ribosomal RNA maturation. NFIC dampens the endoplasmic reticulum stress program through binding to gene promoters and is required for resolution of Tunicamycin-mediated stress. NFIC is down-regulated during caerulein pancreatitis and is required for recovery after damage. Normal human pancreata with low levels of NFIC transcripts display reduced expression of genes down-regulated in Nfic knockout mice. NFIC expression is down-regulated in mouse and human pancreatic ductal adenocarcinoma. Consistently, Nfic knockout mice develop a higher number of mutant Kras-driven pre-neoplastic lesions."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-39291-x"xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Torres A."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Park J.C."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Garcia F."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Malumbres M."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Mendez R."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Munoz J."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "MacDonald R.J."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Real F.X."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Paliwal S."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Millan I."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Martinez-Villarreal J."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Felipe I."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Del Pozo N."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Cobo I."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Bodas C."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/author | "Melia-Aloma J."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/pages | "3761"xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/title | "NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation."xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37353485 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37353485 |