| http://purl.uniprot.org/citations/37362320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37362320 | http://www.w3.org/2000/01/rdf-schema#comment | "Adaptor protein 2-associated kinase 1 (AAK1) is a member of the Ark1/Prk1 family of serine/threonine kinases and plays a role in modulating receptor endocytosis. AAK1 was identified as a potential therapeutic target for the treatment of neuropathic pain when it was shown that AAK1 knock out (KO) mice had a normal response to the acute pain phase of the mouse formalin model, but a reduced response to the persistent pain phase. Herein we report our early work investigating a series of pyrrolo[2,1-f][1,2,4]triazines as part of our efforts to recapitulate this KO phenotype with a potent, small molecule inhibitor of AAK1. The synthesis, structure-activity relationships (SAR), and in vivo evaluation of these AAK1 inhibitors is described.Graphical abstract"xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00044-023-03079-x"xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Ghosh K."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Allen J."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Easton A."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Good A."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Westphal R."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Padmanabha R."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Lentz K."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Muckelbauer J.K."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Parker D.D."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Santone K.S."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Morrison J."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Morgan D."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Dasgupta B."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Khan J."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Macor J.E."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Conway C.M."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Rajamani R."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Bristow L.J."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Grace J."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Bronson J.J."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Kostich W."xsd:string |
| http://purl.uniprot.org/citations/37362320 | http://purl.uniprot.org/core/author | "Camac D."xsd:string |