| http://purl.uniprot.org/citations/37365185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37365185 | http://www.w3.org/2000/01/rdf-schema#comment | "Whether bone marrow modulates systemic metabolism remains unknown. Our recent study suggested that myeloid-derived growth factor (MYDGF) improves insulin resistance. Here, we found that myeloid cell-specific MYDGF deficiency aggravated hepatic inflammation, lipogenesis, and steatosis, and show that myeloid cell-derived MYDGF restoration alleviated hepatic inflammation, lipogenesis, and steatosis. Additionally, recombinant MYDGF attenuated inflammation, lipogenesis, and fat deposition in primary mouse hepatocytes (PMHs). Importantly, inhibitor kappa B kinase beta/nuclear factor-kappa B (IKKβ/NF-κB) signaling is involved in protection of MYDGF on non-alcoholic fatty liver disease (NAFLD). These data revealed that myeloid cell-derived MYDGF alleviates NAFLD and inflammation in a manner involving IKKβ/NF-κB signaling, and serves as a factor involved in the crosstalk between the liver and bone marrow that regulates liver fat metabolism. Bone marrow functions as an endocrine organ and serves as a potential therapeutic target for metabolic disorders."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-023-05904-y"xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/author | "Dong J."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/author | "Ding Y."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/author | "Zhu B."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/author | "Xiang L."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/author | "Guo B."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/author | "Meng B."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/author | "Xiang G."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/pages | "376"xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/title | "Myeloid-derived growth factor alleviates non-alcoholic fatty liver disease alleviates in a manner involving IKKbeta/NF-kappaB signaling."xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37365185 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37365185 |
| http://purl.uniprot.org/citations/37365185 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37365185 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-37365185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37365185 |
| http://purl.uniprot.org/uniprot/#_P08905-mappedCitation-37365185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37365185 |
| http://purl.uniprot.org/uniprot/#_Q9CPT4-mappedCitation-37365185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37365185 |
| http://purl.uniprot.org/uniprot/Q9CPT4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/37365185 |