| http://purl.uniprot.org/citations/37369082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37369082 | http://www.w3.org/2000/01/rdf-schema#comment | "Although absence of interleukin-7 (IL-7) signaling completely abrogates T and B lymphopoiesis in mice, patients with severe combined immunodeficiency caused by mutations in the IL-7 receptor α chain (IL-7Rα) still generate peripheral blood B cells. Consequently, human B lymphopoiesis has been thought to be independent of IL-7 signaling. Using flow cytometric analysis and single-cell RNA sequencing of bone marrow samples from healthy controls and patients who are IL-7Rα deficient, in combination with in vitro modeling of human B-cell differentiation, we demonstrate that IL-7R signaling plays a crucial role in human B lymphopoiesis. IL-7 drives proliferation and expansion of early B-cell progenitors but not of pre-BII large cells and has a limited role in the prevention of cell death. Furthermore, IL-7 guides cell fate decisions by enhancing the expression of BACH2, EBF1, and PAX5, which jointly orchestrate the specification and commitment of early B-cell progenitors. In line with this observation, early B-cell progenitors of patients with IL-7Rα deficiency still expressed myeloid-specific genes. Collectively, our results unveil a previously unknown role for IL-7 signaling in promoting the B-lymphoid fate and expanding early human B-cell progenitors while defining important differences between mice and humans. Our results have implications for hematopoietic stem cell transplantation strategies in patients with T-B+ severe combined immunodeficiency and provide insights into the role of IL-7R signaling in leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood.2023019721"xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Rizzi M."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Schulz A."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Khatri I."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Kuijpers T.W."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "van der Burg M."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Menafra R."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "van Schouwenburg P.A."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Erlacher M."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Lankester A.C."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Pico-Knijnenburg I."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Janowska I."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Kloet S."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Kaiser F.M.P."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Konstantinidis L."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "Korzhenevich J."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/author | "de Gier M."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/pages | "1113-1130"xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/title | "IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion."xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://purl.uniprot.org/core/volume | "142"xsd:string |
| http://purl.uniprot.org/citations/37369082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37369082 |