| http://purl.uniprot.org/citations/37378316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37378316 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetic peripheral neuropathy (DPN) is the most common chronic, progressive complication of diabetes mellitus. The main symptom is sensory loss; the molecular mechanisms are not fully understood. We found that Drosophila fed a high-sugar diet, which induces diabetes-like phenotypes, exhibit impairment of noxious heat avoidance. The impairment of heat avoidance was associated with shrinkage of the leg neurons expressing the Drosophila transient receptor potential channel Painless. Using a candidate genetic screening approach, we identified proteasome modulator 9 as one of the modulators of impairment of heat avoidance. We further showed that proteasome inhibition in the glia reversed the impairment of noxious heat avoidance, and heat-shock proteins and endolysosomal trafficking in the glia mediated the effect of proteasome inhibition. Our results establish Drosophila as a useful system for exploring molecular mechanisms of diet-induced peripheral neuropathy and propose that the glial proteasome is one of the candidate therapeutic targets for DPN."xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2023.106997"xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/author | "Fukui K."xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/author | "Sakata N."xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/author | "Shindo M."xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/author | "Sango K."xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/author | "Saitoe M."xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/author | "Niimi N."xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/author | "Kuromi H."xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/pages | "106997"xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/title | "A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia."xsd:string |
| http://purl.uniprot.org/citations/37378316 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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