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| http://purl.uniprot.org/citations/37378349 | http://www.w3.org/2000/01/rdf-schema#comment | "Animal cell cytokinesis requires activation of the GTPase RhoA (Rho1 in Drosophila), which assembles an F-actin- and myosin II-dependent contractile ring (CR) at the equatorial plasma membrane. CR closure is poorly understood, but involves the multidomain scaffold protein, Anillin. Anillin binds many CR components including F-actin and myosin II (collectively actomyosin), RhoA and the septins. Anillin recruits septins to the CR but the mechanism is unclear. Live imaging of Drosophila S2 cells and HeLa cells revealed that the Anillin N-terminus, which scaffolds actomyosin, cannot recruit septins to the CR. Rather, septin recruitment required the ability of the Anillin C-terminus to bind Rho1-GTP and the presence of the Anillin PH domain, in a sequential mechanism occurring at the plasma membrane, independently of F-actin. Anillin mutations that blocked septin recruitment, but not actomyosin scaffolding, slowed CR closure and disrupted cytokinesis. Thus, CR closure requires coordination of two Rho1-dependent networks: actomyosin and anillo-septin."xsd:string |
| http://purl.uniprot.org/citations/37378349 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2023.106903"xsd:string |
| http://purl.uniprot.org/citations/37378349 | http://purl.uniprot.org/core/author | "Hickson G.R.X."xsd:string |
| http://purl.uniprot.org/citations/37378349 | http://purl.uniprot.org/core/author | "Carim S.C."xsd:string |
| http://purl.uniprot.org/citations/37378349 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
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| http://purl.uniprot.org/citations/37378349 | http://purl.uniprot.org/core/title | "The Rho1 GTPase controls anillo-septin assembly to facilitate contractile ring closure during cytokinesis."xsd:string |
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