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| http://purl.uniprot.org/citations/37379332 | http://www.w3.org/2000/01/rdf-schema#comment | "To respond to the world around them, animals rely on the input of a network of sensory organs distributed throughout the body. Distinct classes of sensory organs are specialized for the detection of specific stimuli such as strain, pressure, or taste. The features that underlie this specialization relate both to the neurons that innervate sensory organs and the accessory cells they comprise. To understand the genetic basis of this diversity of cell types, both within and between sensory organs, we performed single-cell RNA sequencing on the first tarsal segment of the male Drosophila melanogaster foreleg during pupal development. This tissue displays a wide variety of functionally and structurally distinct sensory organs, including campaniform sensilla, mechanosensory bristles, and chemosensory taste bristles, as well as the sex comb, a recently evolved male-specific structure. In this study, we characterize the cellular landscape in which the sensory organs reside, identify a novel cell type that contributes to the construction of the neural lamella, and resolve the transcriptomic differences among support cells within and between sensory organs. We identify the genes that distinguish between mechanosensory and chemosensory neurons, resolve a combinatorial transcription factor code that defines 4 distinct classes of gustatory neurons and several types of mechanosensory neurons, and match the expression of sensory receptor genes to specific neuron classes. Collectively, our work identifies core genetic features of a variety of sensory organs and provides a rich, annotated resource for studying their development and function."xsd:string |
| http://purl.uniprot.org/citations/37379332 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.3002148"xsd:string |
| http://purl.uniprot.org/citations/37379332 | http://purl.uniprot.org/core/author | "Kopp A."xsd:string |
| http://purl.uniprot.org/citations/37379332 | http://purl.uniprot.org/core/author | "Barmina O."xsd:string |
| http://purl.uniprot.org/citations/37379332 | http://purl.uniprot.org/core/author | "Hopkins B.R."xsd:string |
| http://purl.uniprot.org/citations/37379332 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37379332 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/37379332 | http://purl.uniprot.org/core/pages | "e3002148"xsd:string |
| http://purl.uniprot.org/citations/37379332 | http://purl.uniprot.org/core/title | "A single-cell atlas of the sexually dimorphic Drosophila foreleg and its sensory organs during development."xsd:string |
| http://purl.uniprot.org/citations/37379332 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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