| http://purl.uniprot.org/citations/37384525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37384525 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurexin synaptic organizing proteins are central to a genetic risk pathway in neuropsychiatric disorders. Neurexins also exemplify molecular diversity in the brain, with over a thousand alternatively spliced forms and further structural heterogeneity contributed by heparan sulfate glycan modification. Yet, interactions between these modes of post-transcriptional and post-translational modification have not been studied. We reveal that these regulatory modes converge on neurexin-1 splice site 5 (S5): the S5 insert increases the number of heparan sulfate chains. This is associated with reduced neurexin-1 protein level and reduced glutamatergic neurotransmitter release. Exclusion of neurexin-1 S5 in mice boosts neurotransmission without altering the AMPA/NMDA ratio and shifts communication and repetitive behavior away from phenotypes associated with autism spectrum disorders. Thus, neurexin-1 S5 acts as a synaptic rheostat to impact behavior through the intersection of RNA processing and glycobiology. These findings position NRXN1 S5 as a potential therapeutic target to restore function in neuropsychiatric disorders."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2023.112714"xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/author | "Ge Y."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/author | "Brown R.E."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/author | "Zuo L."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/author | "Oku S."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/author | "Craig A.M."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/author | "Delhaye M."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/author | "Bellefontaine M."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/author | "Garden J."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/author | "Roddick K.M."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/pages | "112714"xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/title | "Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors."xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/37384525 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37384525 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JE65-mappedCitation-37384525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37384525 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JES8-mappedCitation-37384525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37384525 |
| http://purl.uniprot.org/uniprot/#_E0CY11-mappedCitation-37384525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37384525 |