| http://purl.uniprot.org/citations/37390818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37390818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37390818 | http://www.w3.org/2000/01/rdf-schema#comment | "Maintaining a highly acidic lysosomal pH is central to cellular physiology. Here, we use functional proteomics, single-particle cryo-EM, electrophysiology, and in vivo imaging to unravel a key biological function of human lysosome-associated membrane proteins (LAMP-1 and LAMP-2) in regulating lysosomal pH homeostasis. Despite being widely used as a lysosomal marker, the physiological functions of the LAMP proteins have long been overlooked. We show that LAMP-1 and LAMP-2 directly interact with and inhibit the activity of the lysosomal cation channel TMEM175, a key player in lysosomal pH homeostasis implicated in Parkinson's disease. This LAMP inhibition mitigates the proton conduction of TMEM175 and facilitates lysosomal acidification to a lower pH environment crucial for optimal hydrolase activity. Disrupting the LAMP-TMEM175 interaction alkalinizes the lysosomal pH and compromises the lysosomal hydrolytic function. In light of the ever-increasing importance of lysosomes to cellular physiology and diseases, our data have widespread implications for lysosomal biology."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2023.06.004"xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2023.06.004"xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Zeng W."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Zeng W."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Lee W.R."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Lee W.R."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Liou J."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/author | "Liou J."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/pages | "2524-2539"xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/pages | "2524-2539"xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/title | "Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel."xsd:string |
| http://purl.uniprot.org/citations/37390818 | http://purl.uniprot.org/core/title | "Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel."xsd:string |