| http://purl.uniprot.org/citations/37414772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37414772 | http://www.w3.org/2000/01/rdf-schema#comment | "A lingering question in developmental biology has centered on how transcription factors with widespread distribution in vertebrate embryos can perform tissue-specific functions. Here, using the murine hindlimb as a model, we investigate the elusive mechanisms whereby PBX TALE homeoproteins, viewed primarily as HOX cofactors, attain context-specific developmental roles despite ubiquitous presence in the embryo. We first demonstrate that mesenchymal-specific loss of PBX1/2 or the transcriptional regulator HAND2 generates similar limb phenotypes. By combining tissue-specific and temporally controlled mutagenesis with multi-omics approaches, we reconstruct a gene regulatory network (GRN) at organismal-level resolution that is collaboratively directed by PBX1/2 and HAND2 interactions in subsets of posterior hindlimb mesenchymal cells. Genome-wide profiling of PBX1 binding across multiple embryonic tissues further reveals that HAND2 interacts with subsets of PBX-bound regions to regulate limb-specific GRNs. Our research elucidates fundamental principles by which promiscuous transcription factors cooperate with cofactors that display domain-restricted localization to instruct tissue-specific developmental programs."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-39443-z"xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Visel A."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Bobola N."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Selleri L."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Zuniga A."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Morabito A."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Zeller R."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Losa M."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Mackem S."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Capellini T.D."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Barozzi I."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Osterwalder M."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Zarrineh P."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Benazet J.D."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Dickel D."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Girdziusaite A."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Chacon B.H."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/author | "Hermosilla-Aguayo V."xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/pages | "3993"xsd:string |
| http://purl.uniprot.org/citations/37414772 | http://purl.uniprot.org/core/title | "A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2."xsd:string |