| http://purl.uniprot.org/citations/37418322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37418322 | http://www.w3.org/2000/01/rdf-schema#comment | "Homeostatic synaptic plasticity adjusts the strength of synapses to restrain neuronal activity within a physiological range. Postsynaptic guanylate kinase-associated protein (GKAP) controls the bidirectional synaptic scaling of AMPA receptors (AMPARs); however, mechanisms by which chronic activity triggers cytoskeletal remodeling to downscale synaptic transmission are barely understood. Here, we report that the microtubule-dependent kinesin motor Kif21b binds GKAP and likewise is located in dendritic spines in a myosin Va- and neuronal-activity-dependent manner. Kif21b depletion unexpectedly alters actin dynamics in spines, and adaptation of actin turnover following chronic activity is lost in Kif21b-knockout neurons. Consistent with a role of the kinesin in regulating actin dynamics, Kif21b overexpression promotes actin polymerization. Moreover, Kif21b controls GKAP removal from spines and the decrease of GluA2-containing AMPARs from the neuronal surface, thereby inducing homeostatic synaptic downscaling. Our data highlight a critical role of Kif21b at the synaptic actin cytoskeleton underlying homeostatic scaling of neuronal firing."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2023.112743"xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Kneussel M."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Schweizer M."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Gee C.E."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Janiesch P.C."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Mikhaylova M."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Thies E."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Gromova K.V."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Konietzny A."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Durst C.D."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Lutzenkirchen F.P."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/author | "Stajano D."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/pages | "112743"xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/title | "The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling."xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/37418322 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37418322 |
| http://purl.uniprot.org/citations/37418322 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37418322 |
| http://purl.uniprot.org/uniprot/#_E9Q0A4-mappedCitation-37418322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37418322 |
| http://purl.uniprot.org/uniprot/#_A1L0T4-mappedCitation-37418322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37418322 |
| http://purl.uniprot.org/uniprot/#_F8VQE2-mappedCitation-37418322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37418322 |