| http://purl.uniprot.org/citations/37424431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37424431 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell identity is specified by a core transcriptional regulatory circuitry (CoRC), typically limited to a small set of interconnected cell-specific transcription factors (TFs). By mining global hepatic TF regulons, we reveal a more complex organization of the transcriptional regulatory network controlling hepatocyte identity. We show that tight functional interconnections controlling hepatocyte identity extend to non-cell-specific TFs beyond the CoRC, which we call hepatocyte identity (Hep-ID)CONNECT TFs. Besides controlling identity effector genes, Hep-IDCONNECT TFs also engage in reciprocal transcriptional regulation with TFs of the CoRC. In homeostatic basal conditions, this translates into Hep-IDCONNECT TFs being involved in fine tuning CoRC TF expression including their rhythmic expression patterns. Moreover, a role for Hep-IDCONNECT TFs in the control of hepatocyte identity is revealed in dedifferentiated hepatocytes where Hep-IDCONNECT TFs are able to reset CoRC TF expression. This is observed upon activation of NR1H3 or THRB in hepatocarcinoma or in hepatocytes subjected to inflammation-induced loss of identity. Our study establishes that hepatocyte identity is controlled by an extended array of TFs beyond the CoRC."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.202357020"xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Staels B."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Dubois V."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Lefebvre P."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Eeckhoute J."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Gauthier K."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Marot G."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Berthier A."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Dubuquoy L."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Boulet C."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Gheeraert C."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Dubois-Chevalier J."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Guille L."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/author | "Fourcot M."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/pages | "e57020"xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/title | "An extended transcription factor regulatory network controls hepatocyte identity."xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/37424431 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37424431 |
| http://purl.uniprot.org/citations/37424431 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37424431 |
| http://purl.uniprot.org/uniprot/#_A0A286YD21-mappedCitation-37424431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37424431 |
| http://purl.uniprot.org/uniprot/#_A0A286YDB1-mappedCitation-37424431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37424431 |