http://purl.uniprot.org/citations/37453225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/37453225 | http://www.w3.org/2000/01/rdf-schema#comment | "The faithful splicing of pre-mRNA is critical for accurate gene expression. Dysregulation of pre-mRNA splicing has been associated with several human diseases including cancer. The ubiquitin-like protein Hub1/UBL5 binds to the substrates non-covalently and promotes pre-mRNA splicing. Additionally, UBL5 promotes the common fragile sites stability and the Fanconi anemia pathway of DNA damage repair. These functions strongly suggests that UBL5 could potentially be implicated in cancer. Therefore, we analyzed the UBL5 expression in TCGA tumor sample datasets and observed the differences between tumor and normal tissues among different tumor subtypes. We have noticed the alteration frequency of UBL5 in TCGA tumor samples. Altogether, this review summarizes the UBL5 functions and discusses its putative role in tumorigenesis."xsd:string |
http://purl.uniprot.org/citations/37453225 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2023.106445"xsd:string |
http://purl.uniprot.org/citations/37453225 | http://purl.uniprot.org/core/author | "Kolathur K.K."xsd:string |
http://purl.uniprot.org/citations/37453225 | http://purl.uniprot.org/core/author | "Barve S."xsd:string |
http://purl.uniprot.org/citations/37453225 | http://purl.uniprot.org/core/author | "Mallya S."xsd:string |
http://purl.uniprot.org/citations/37453225 | http://purl.uniprot.org/core/author | "Bojja S.L."xsd:string |
http://purl.uniprot.org/citations/37453225 | http://purl.uniprot.org/core/author | "Wagle M.M."xsd:string |
http://purl.uniprot.org/citations/37453225 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
http://purl.uniprot.org/citations/37453225 | http://purl.uniprot.org/core/name | "Int J Biochem Cell Biol"xsd:string |
http://purl.uniprot.org/citations/37453225 | http://purl.uniprot.org/core/pages | "106445"xsd:string |
http://purl.uniprot.org/citations/37453225 | http://purl.uniprot.org/core/title | "Moonlighting functions of the ubiquitin-like protein, Hub1/UBL-5."xsd:string |
http://purl.uniprot.org/citations/37453225 | http://purl.uniprot.org/core/volume | "162"xsd:string |
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