| http://purl.uniprot.org/citations/37454216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37454216 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunotherapy has become established as major treatment modality for multiple types of solid tumors, including colorectal cancer. Identifying novel immunotherapeutic targets to enhance anti-tumor immunity and sensitize current immune checkpoint blockade (ICB) in colorectal cancer is needed. Here we report the histone demethylase PHD finger protein 8 (PHF8, KDM7B), a Jumonji C domain-containing protein that erases repressive histone methyl marks, as an essential mediator of immune escape. Ablation the function of PHF8 abrogates tumor growth, activates anti-tumor immune memory, and augments sensitivity to ICB therapy in mouse models of colorectal cancer. Strikingly, tumor PHF8 deletion stimulates a viral mimicry response in colorectal cancer cells, where the depletion of key components of endogenous nucleic acid sensing diminishes PHF8 loss-meditated antiviral immune responses and anti-tumor effects in vivo. Mechanistically, PHF8 inhibition elicits H3K9me3-dependent retrotransposon activation by promoting proteasomal degradation of the H3K9 methyltransferase SETDB1 in a demethylase-independent manner. Moreover, PHF8 expression is anti-correlated with canonical immune signatures and antiviral immune responses in human colorectal adenocarcinoma. Overall, our study establishes PHF8 as an epigenetic checkpoint, and targeting PHF8 is a promising viral mimicry-inducing approach to enhance intrinsic anti-tumor immunity or to conquer immune resistance."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-39943-y"xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "He J."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Hong G."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Pang X."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Feng J."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Hu L."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Lian Z."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Wong J."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/author | "Yuan K."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/pages | "4225"xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/title | "Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons."xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/37454216 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/37454216 |
| http://purl.uniprot.org/citations/37454216 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/37454216 |
| http://purl.uniprot.org/uniprot/#_A2ABV3-mappedCitation-37454216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/37454216 |