| http://purl.uniprot.org/citations/37462140 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37462140 | http://www.w3.org/2000/01/rdf-schema#comment | "The biological functions of circTLK1 in acute kidney injury (AKI), which mainly results from renal ischemia-reperfusion (IR), remain largely unknown. HK-2 cell treatment with oxygen and glucose deprivation, reoxygenation, and glucose (OGD/R) was used to simulate an AKI model that was mainly caused by renal IR. Then, the circTLK1 expression level in HK-2 cells treated with OGD/R was assessed by quantitative reverse transcription polymerase chain reaction (RT-qPCR). Functional experiments were performed with circTLK1 knockdown of HK-2 cells via Cell Counting Kit-8 (CCK8), flow cytometry (FCM), RT-qPCR, and western blotting. The circTLK1-miRNAs-mRNAs network was constructed following the ceRNA mechanism and visualized by Cytoscape software to investigate the mechanism of circTLK1 in AKI. RT-qPCR was performed to verify the relationship between circTLK1, miR-136-5p, and Bcl2. The level of miR-136-5p was knocked down to ensure its function in OGD/R-triggered apoptosis through experiments, including CCK8, FCM, RT-qPCR, and western blotting. CircTLK1 was downregulated in HK-2 cells subjected to OGD/R treatment and in mouse kidney tissues after renal IR, but the expression of miR-136-5p was the opposite. Interference with circTLK1 expression accelerated HK-2 cell apoptosis, which was overturned by miR-136-5p inhibitors. CircTLK1 targets miR-136-5p to upregulate Bcl2 expression and attenuate apoptosis in HK-2 cells. These data revealed the possible role of circTLK1 as a new biomarker for diagnosis as well as a target in AKI through the miR-136-5p/Bcl2 signaling axis."xsd:string |
| http://purl.uniprot.org/citations/37462140 | http://purl.org/dc/terms/identifier | "doi:10.1080/0886022x.2023.2236219"xsd:string |
| http://purl.uniprot.org/citations/37462140 | http://purl.uniprot.org/core/author | "Lu A."xsd:string |
| http://purl.uniprot.org/citations/37462140 | http://purl.uniprot.org/core/author | "Yao S."xsd:string |
| http://purl.uniprot.org/citations/37462140 | http://purl.uniprot.org/core/author | "Kuang L."xsd:string |
| http://purl.uniprot.org/citations/37462140 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37462140 | http://purl.uniprot.org/core/name | "Ren Fail"xsd:string |
| http://purl.uniprot.org/citations/37462140 | http://purl.uniprot.org/core/pages | "2236219"xsd:string |
| http://purl.uniprot.org/citations/37462140 | http://purl.uniprot.org/core/title | "CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis."xsd:string |
| http://purl.uniprot.org/citations/37462140 | http://purl.uniprot.org/core/volume | "45"xsd:string |
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