| http://purl.uniprot.org/citations/37468522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37468522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/37468522 | http://www.w3.org/2000/01/rdf-schema#comment | "G-proteins function as molecular switches to power cofactor translocation and confer fidelity in metal trafficking. The G-protein, MMAA, together with MMAB, an adenosyltransferase, orchestrate cofactor delivery and repair of B12-dependent human methylmalonyl-CoA mutase (MMUT). The mechanism by which the complex assembles and moves a >1300 Da cargo, or fails in disease, are poorly understood. Herein, we report the crystal structure of the human MMUT-MMAA nano-assembly, which reveals a dramatic 180° rotation of the B12 domain, exposing it to solvent. The complex, stabilized by MMAA wedging between two MMUT domains, leads to ordering of the switch I and III loops, revealing the molecular basis of mutase-dependent GTPase activation. The structure explains the biochemical penalties incurred by methylmalonic aciduria-causing mutations that reside at the MMAA-MMUT interfaces we identify here."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-40077-4"xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-023-40077-4"xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Banerjee R."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Banerjee R."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Gouda H."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Gouda H."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Ruetz M."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Ruetz M."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Mascarenhas R."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Mascarenhas R."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Heitman N."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Heitman N."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Yaw M."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/author | "Yaw M."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/pages | "4332"xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/pages | "4332"xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/title | "Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B12 delivery and repair."xsd:string |
| http://purl.uniprot.org/citations/37468522 | http://purl.uniprot.org/core/title | "Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B12 delivery and repair."xsd:string |